Does CBD interact with other medications?


Does CBD interact with other medications?

Prescription Medications and CBD: The Good and the Bad

With CBD sweeping the country, the possibility of complications from consuming CBD alongside other prescribed medications is high. There is limited research to indicate what kind of medications can cause a reaction because of variances in the studies. There is always a chance that medication will react negatively with CBD that is outside normal studies, so working with a trained medical doctor should be a first step towards avoiding possibly deadly consequences.

What is CBD?

Cannabidiol (CBD) is a chemical found in the Cannabis Sativa plant. It is in both strains of marijuana and hemp. CBD has antipsychotic effects that influence the brain in the way that it can affect mood, mental functions, and control pain.

How can CBD help the brain and body?

While only one form of epilepsy (Dravet Syndrome) has been shown as being treated effectively with CBD. Prescribed and used for a host of disorders, CBD can interact with the two main cannabinoid receptors in the brain: CB1 and CB2. By influencing these two receptors, people have found relief for the following conditions:

  • Pain
  • Nausea
  • Migraines
  • Anxiety
  • Seizures
  • Inflammation
  • PTSD
  • Depression

Clinical testing is underway for some of these conditions, though testing is limited because CBD is still labeled a controlled substance by the Federal Government. The Farm Bill, passed in 2018, allowed for the distribution of hemp and CBD products with less than 0.3 percent THC in the makeup. This opened the door for a lot of people to receive access to products that can help them feel better.

Are there any side effects from taking CBD?

CBD does not produce any harmful effects on its own. It has failed to show any noticeable effects that are negative or dangerous to the user in any of the completed clinical studies. It also failed to show any sign of addiction or abuse possibilities.

Does CBD interact with other types of medications?

The only possible problems that can arise from taking CBD can occur when it interacts with other prescribed medications. Currently, there are few reported problems with using CBD with other types of medicines, but that does not mean there will not be problems for some people on certain medications.

A human can tolerate amounts of CBD up to 600mg without it resulting in psychotic problems, though there are only limited studies currently available to peruse and are all of the mixed quality. The Federal Government does not regulate CBD, so the reliability of the product used or the purity of it is unverified.

There are concerns with mothers consuming CBD and what it is doing to the fetus, as it is hard to determine what will affect one person and how it will affect another. There is a study that indicates that it can prevent neurological disturbances in children born of mothers that experienced a prenatal infection before the end of their second trimester of pregnancy.

Prenatal infections are linked to a higher likelihood of developing neuropsychiatric disorders like schizophrenia. The study provides positive evidence that CBD can prevent hallucinations of cognitive impairments that disrupt a normal healthy person’s life.

CBD does have the potential for public harm as it can cause pharmacodynamic and pharmacokinetic changes in the brain and the body. The human liver extensively metabolizes CBD. While this may not be a bad thing, it could cause additional problems for people with liver disorders or who drink extensively.

The current research indicates a growing concern that adverse drug events (ADE) and Drug-to-drug interactions (DDI) are still a potential problem. There is current evidence that medications taken to help with absorption or metabolism are potential candidates for adverse drug events and drug-to-drug interaction problems, as the use of these medications are inhibited when CBD is consumed in addition to them.

The difficulty with producing comprehensive studies on CBD is the variety of strains all need to be tested against every single possible drug. The current research says that CBD can actively interfere when taken with other types of medications, particularly strains of CBD that interact with the CYP3A4 and 2C19 inhibitors in the brain.

One study found very little evidence of a strong reaction to stimulating the CYP2C19 enzymes, and all the participants in the study came out well. The study tested a CBD/THC spray, which can cause different types of body interactions as it is a spray and not the more commonly ingested oil.

A more recent and comprehensive review of CBD found that nearly half of the participants consuming CBD products alongside their regular medicines had ADE reactions. The most common adverse drug reactions were sleep disturbances, anemia, infections, and transaminase elevations. The study showed the possible problems with metabolism-based medications could react with CBD when it is introduced to the body.

Final Thoughts

CBD can have some benefits for certain people, depending on the condition that needs treating. The drug, Charlotte’s Web CBD Oil, has proven effective at treating Dravet Syndrome, but other CBD products may work better than the oil. The CBD oil reduced the sufferers’ epileptic seizures from upwards of three hundred a week to maybe three a month.

More study into adverse reactions is needed for a more comprehensive picture of what CBD can and cannot do is needed. While these are currently under research in many facilities across the country, it will still be many years before a complete picture of CBD is available for the public.